4YHF
Bruton's tyrosine kinase in complex with a t-butyl cyanoacrylamide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein kinase BTK | polymer | 278 | 32269.0 | 2 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | A, B | (2S)-2-({(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | non-polymer | 523.6 | 2 | Chemie (4C9) | |||
| 3 | B, A | SODIUM ION | non-polymer | 23.0 | 24 | Chemie (NA) | |||
| 4 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 5 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | A, B | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 7 | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64538.0 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 2631.9 | |
| All* | Total formula weight | 67170.0 |
