4YDK
Crystal structure of broadly and potently neutralizing antibody C38-VRC16.01 in complex with HIV-1 clade AE strain 93TH057 gp120
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Envelope glycoprotein gp160,Envelope glycoprotein gp160 | polymer | 353 | 39211.4 | 1 | UniProt (Q0ED31) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | B (H) | HEAVY CHAIN OF ANTIBODY C38-VRC16.01 | polymer | 234 | 25132.1 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | LIGHT CHAIN OF ANTIBODY C38-VRC16.01 | polymer | 214 | 23567.1 | 1 | Homo sapiens (Human) | ||
| 4 | D, E, F, G, H... (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 5 | BA, CA, N, O, P... (L, G, H) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) | |||
| 6 | AA, DA, EA, FA, GA... (H, L, G) | GLYCEROL | non-polymer | 92.1 | 13 | Chemie (GOL) | |||
| 7 | S (G) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 1 | Chemie (NHE) | |||
| 8 | IA, JA, KA (G, H, L) | water | water | 18.0 | 462 | Chemie (HOH) |
Sequence modifications
G: 44 - 123 (UniProt: Q0ED31)
G: 199 - 301 (UniProt: Q0ED31)
G: 324 - 492 (UniProt: Q0ED31)
G: 199 - 301 (UniProt: Q0ED31)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | linker |
| Gly 198 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 318 | - | linker |
| Gly 319 | - | linker |
| Ser 320 | - | linker |
| Gly 321 | - | linker |
| Ser 322 | - | linker |
| Gly 323 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 87910.6 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 4359.4 | |
| All* | Total formula weight | 92270.0 |
