4YDE

CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE BINARY COMPLEX WITH THE ISOPRENOID FARNESYLDIPHOSPHATE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	polymer	329	39236.8	1	UniProt (Q5APE8)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
2	B (B)	Protein farnesyltransferase/geranylgeranyltransferase type-1 Subunit beta	polymer	587	66693.3	1	UniProt (Q59LE1)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
3	C, F (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	D (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	E (B)	(3R,7S)-3,7,11-trimethyldodecyl trihydrogen diphosphate	non-polymer		388.4	1	Chemie (4C7)
6	G, H (A, B)	water	water		18.0	150	Chemie (HOH)

Sequence modifications

A: 1 - 305 (UniProt: Q5APE8)

PDB	External Database	Details
Met -23	-	initiating methionine
Gly -22	-	expression tag
Ser -21	-	expression tag
Ser -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Ser -13	-	expression tag
Gln -12	-	expression tag
Asp -11	-	expression tag
Pro -10	-	expression tag
Asn -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
Ala -5	-	expression tag
Arg -4	-	expression tag
Leu -3	-	expression tag
Gln -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105930.1
Non-Polymers*	Number of molecules	4
	Total formula weight	577.9
All*	Total formula weight	106508.0

*Water molecules are not included.