4YCW

Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F	Lysine--tRNA ligase	polymer	513	59201.1	4	UniProt (Q15046) Pfam (PF01336) Pfam (PF00152) In PDB	Homo sapiens (Human)	Lysyl-tRNA synthetase,LysRS
2	C, D, G, H	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	polymer	42	4911.7	4	UniProt (Q13155) Pfam (PF16780) In PDB	Homo sapiens (Human)	Multisynthase complex auxiliary component p38,Protein JTV-1
3	A, B, E, F	LYSINE	non-polymer		147.2	4	Chemie (LYS)
4	A, B, E, F	cladosporin	non-polymer		292.3	4	Chemie (KRS)
5		water	water		18.0	9	Chemie (HOH)

Sequence modifications

A, B, E, F: 70 - 581 (UniProt: Q15046)

PDB	External Database	Details
Met 69	-	initiating methionine
Thr 300	Pro 328	conflict
Val 321	Gln 349	conflict
Ser 337	Thr 365	conflict

C, D, G, H: 1 - 36 (UniProt: Q13155)

PDB	External Database	Details
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	256451.1
Non-Polymers*	Number of molecules	8
	Total formula weight	1758.1
All*	Total formula weight	258209.2

*Water molecules are not included.