4Y9B

Crystal structure of V30M mutated transthyretin in complex with alpha-mangostin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	159	17342.6	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (Human)	ATTR,Prealbumin,TBPA
2	A, B	1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one	non-polymer		410.5	2	Chemie (MKS)
3	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5		water	water		18.0	241	Chemie (HOH)

Sequence modifications

A, B: -19 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -31	-	expression tag
Arg -30	-	expression tag
Gly -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Met 30	Val 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34685.2
Non-Polymers*	Number of molecules	5
	Total formula weight	931.9
All*	Total formula weight	35617.1

*Water molecules are not included.