4Y99

Core domain of human cardiac troponin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Troponin C, slow skeletal and cardiac muscles	polymer	161	18401.4	1	UniProt (P63316) Pfam (PF13833) Pfam (PF13499) In PDB	Homo sapiens (Human)	TN-C
2	B	Troponin T, cardiac muscle	polymer	106	12842.8	1	UniProt (P45379) Pfam (PF00992) In PDB	Homo sapiens (Human)	TnTc,Cardiac muscle troponin T,cTnT
3	C	Troponin I, cardiac muscle	polymer	210	23994.6	1	UniProt (P19429) Pfam (PF11636) Pfam (PF00992) In PDB	Homo sapiens (Human)	Cardiac troponin I
4	A	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
5	A, B, C	DIMETHYL SULFOXIDE	non-polymer		78.1	6	Chemie (DMS)
6		water	water		18.0	102	Chemie (HOH)

Sequence modifications

A: 1 - 161 (UniProt: P63316)

PDB	External Database	Details
Ser 35	Cys 35	engineered mutation
Ser 84	Cys 84	engineered mutation
Glu 115	Asp 115	conflict

B: 183 - 288 (UniProt: P45379)

PDB	External Database	Details
Thr 239	Ser 249	conflict

C: 1 - 210 (UniProt: P19429)

PDB	External Database	Details
Ala 80	Cys 80	engineered mutation
Ala 97	Cys 97	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55238.7
Non-Polymers*	Number of molecules	9
	Total formula weight	589.0
All*	Total formula weight	55827.7

*Water molecules are not included.