4Y99
Core domain of human cardiac troponin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Troponin C, slow skeletal and cardiac muscles | polymer | 161 | 18401.4 | 1 | UniProt (P63316) Pfam (PF13833) Pfam (PF13499) | Homo sapiens (Human) | TN-C |
| 2 | B (B) | Troponin T, cardiac muscle | polymer | 106 | 12842.8 | 1 | UniProt (P45379) Pfam (PF00992) | Homo sapiens (Human) | TnTc,Cardiac muscle troponin T,cTnT |
| 3 | C (C) | Troponin I, cardiac muscle | polymer | 210 | 23994.6 | 1 | UniProt (P19429) Pfam (PF11636) Pfam (PF00992) | Homo sapiens (Human) | Cardiac troponin I |
| 4 | D, E, F (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 5 | G, H, I, J, K... (A, B, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 6 | Chemie (DMS) | |||
| 6 | M, N, O (A, B, C) | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A: 1 - 161 (UniProt: P63316)
B: 183 - 288 (UniProt: P45379)
C: 1 - 210 (UniProt: P19429)
| PDB | External Database | Details |
|---|---|---|
| Ser 35 | Cys 35 | engineered mutation |
| Ser 84 | Cys 84 | engineered mutation |
| Glu 115 | Asp 115 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 239 | Ser 249 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 80 | Cys 80 | engineered mutation |
| Ala 97 | Cys 97 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 55238.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 589.0 | |
| All* | Total formula weight | 55827.7 |
