4Y93
Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Non-specific protein-tyrosine kinase,Non-specific protein-tyrosine kinase | polymer | 446 | 51892.6 | 1 | UniProt (Q3ZC95) Pfam (PF00169) Pfam (PF00779) Pfam (PF07714) | Bos taurus (Bovine) | |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide | non-polymer | 579.7 | 1 | Chemie (746) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E (A) | water | water | 18.0 | 518 | Chemie (HOH) |
Sequence modifications
A: 1 - 168 (UniProt: Q3ZC95)
A: 384 - 658 (UniProt: Q3ZC95)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 169 | - | linker |
| Ala 170 | - | linker |
| Met 542 | Leu 542 | engineered mutation |
| Thr 543 | Ser 543 | engineered mutation |
| Thr 555 | Val 555 | engineered mutation |
| Lys 562 | Arg 562 | engineered mutation |
| Ala 564 | Ser 564 | engineered mutation |
| Ser 565 | Pro 565 | engineered mutation |
| Pro 617 | Tyr 617 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51892.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 685.2 | |
| All* | Total formula weight | 52577.8 |
