4Y8W
Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Cytochrome P450 21-hydroxylase | polymer | 482 | 54539.2 | 3 | UniProt (Q16874) Pfam (PF00067) UniProt (by SIFTS) (P08686) In PDB | Homo sapiens (Human) | Cytochrome P450,family 21,subfamily A,polypeptide 2,isoform CRA_b,DJ34F7.3 (Cytochrome P450,subfamily XXIA (Steroid 21-hydroxylase,congenital adrenal hyperplasia),polypeptide 2 (CYP21,P450c21B)),Steroid 21-hydroxylase,cDNA,FLJ95495,Homo sapiens cytochrome P450,polypeptide 2(CYP21A2),mRNA |
2 | A, B, C | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A, B, C | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
4 | A, B, C | PROGESTERONE | non-polymer | 314.5 | 3 | Chemie (STR) | |||
5 | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B, C: 30 - 495 (UniProt: Q16874)
PDB | External Database | Details |
---|---|---|
Met 20 | - | initiating methionine |
Ala 21 | - | expression tag |
Lys 22 | - | expression tag |
Lys 23 | - | expression tag |
Thr 24 | - | expression tag |
Ser 25 | - | expression tag |
Ser 26 | - | expression tag |
Lys 27 | - | expression tag |
Gly 28 | - | expression tag |
Lys 29 | - | expression tag |
His 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
His 500 | - | expression tag |
His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 163617.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3177.1 | |
All* | Total formula weight | 166794.6 |