4Y86
Crystal structure of PDE9 in complex with racemic inhibitor C33
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | polymer | 533 | 61789.1 | 2 | UniProt (O76083) Pfam (PF00233) | Homo sapiens (Human) | |
| 2 | C (A) | 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | non-polymer | 357.8 | 1 | Chemie (49D) | |||
| 3 | D, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F (B) | 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | non-polymer | 357.8 | 1 | Chemie (49E) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 123578.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 895.1 | |
| All* | Total formula weight | 124473.3 |
