4Y73
Crystal structure of IRAK4 kinase domain with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Interleukin-1 receptor-associated kinase 4 | polymer | 302 | 34013.2 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | A, B, C, D | 5-{[(1R,2S)-2-aminocyclohexyl]amino}-N-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 422.4 | 4 | Chemie (XPY) | |||
| 3 | water | water | 18.0 | 395 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 159 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 136053.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1689.6 | |
| All* | Total formula weight | 137742.6 |
