4Y6P
Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC177, and manganese
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast | polymer | 422 | 48164.5 | 2 | UniProt (Q8IKG4) Pfam (PF02670) Pfam (PF08436) Pfam (PF13288) | Plasmodium falciparum 3D7 | DXP reductoisomerase |
| 2 | C, E (A, B) | [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-6-phenylhexyl]phosphonic acid | non-polymer | 329.3 | 2 | Chemie (R77) | |||
| 3 | D, F (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | G (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | H (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 573 | Chemie (HOH) |
Sequence modifications
A, B: 75 - 488 (UniProt: Q8IKG4)
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
| Ala 68 | - | expression tag |
| His 69 | - | expression tag |
| His 70 | - | expression tag |
| His 71 | - | expression tag |
| His 72 | - | expression tag |
| His 73 | - | expression tag |
| His 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96329.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 904.7 | |
| All* | Total formula weight | 97233.6 |
