4Y3K

Structure of Vaspin mutant E379S

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serpin A12	polymer	414	47551.8	2	UniProt (Q8IW75) Pfam (PF00079)	Homo sapiens (Human)	OL-64,Visceral adipose tissue-derived serine protease inhibitor,Vaspin,Visceral adipose-specific serpin
2	C, I, J, L, M (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	D, E, F, G, H... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
4	O, P (A, B)	water	water		18.0	188	Chemie (HOH)

Sequence modifications

A, B: 22 - 414 (UniProt: Q8IW75)

PDB	External Database	Details
Gly 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Ser 12	-	expression tag
Ser 13	-	expression tag
Gly 14	-	expression tag
His 15	-	expression tag
Ile 16	-	expression tag
Glu 17	-	expression tag
Gly 18	-	expression tag
Arg 19	-	expression tag
His 20	-	expression tag
Met 21	-	expression tag
Ser 379	Glu 379	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95103.7
Non-Polymers*	Number of molecules	12
	Total formula weight	914.8
All*	Total formula weight	96018.4

*Water molecules are not included.