4XZN
Crystal structure of the methylated K125R/V301L AKR1B10 Holoenzyme
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | X | Aldo-keto reductase family 1 member B10 | polymer | 316 | 36447.1 | 1 | UniProt (O60218) Pfam (PF00248) In PDB | Homo sapiens (Human) | ARL-1,Aldose reductase-like,Aldose reductase-related protein,hARP,Small intestine reductase,SI reductase |
| 2 | X | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | X | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
X: 1 - 316 (UniProt: O60218)
| PDB | External Database | Details |
|---|---|---|
| Arg 125 | Lys 125 | engineered mutation |
| Leu 301 | Val 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36447.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 805.5 | |
| All* | Total formula weight | 37252.6 |
