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4XZH

Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Aldose reductasepolymer31635898.32UniProt (P15121)
Pfam (PF00248)
Homo sapiens (Human)AR,Aldehyde reductase,Aldo-keto reductase family 1 member B1
2C, E
(A, B)
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.42Chemie (NAP)
3D, F
(A, B)
[3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetic acidnon-polymer339.72Chemie (48I)
4G, H
(A, B)
waterwater18.0778Chemie (HOH)
Sequence modifications
A, B: 0 - 315 (UniProt: P15121)
PDBExternal DatabaseDetails
Ile 4Leu 5conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight71796.7
Non-Polymers*Number of molecules4
Total formula weight2166.2
All*Total formula weight73962.9
*Water molecules are not included.

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PDB entries from 2025-07-23

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