4XW6

X-ray structure of PKAc with ADP, free phosphate ion, CP20, magnesium ions

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	cAMP-dependent protein kinase catalytic subunit alpha	polymer	356	41566.2	1	UniProt (P05132) Pfam (PF00069)	Mus musculus (Mouse)	PKA C-alpha
2	B (B)	cAMP-dependent protein kinase inhibitor alpha	polymer	20	2215.5	1	UniProt (by SIFTS) (P61926)	Oryctolagus cuniculus	PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform
3	C, D (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
5	F (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6	G, H (A, B)	water	water		18.0	377	Chemie (HOH)

Sequence modifications

A: 14 - 350 (UniProt: P05132)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Gly 1	-	expression tag
Asn 2	-	expression tag
Ala 3	-	expression tag
Ala 4	-	expression tag
Ala 5	-	expression tag
Ala 6	-	expression tag
Lys 7	-	expression tag
Lys 8	-	expression tag
Gly 9	-	expression tag
Ser 10	-	expression tag
Glu 11	-	expression tag
Gln 12	-	expression tag
Glu 13	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43781.6
Non-Polymers*	Number of molecules	4
	Total formula weight	570.8
All*	Total formula weight	44352.4

*Water molecules are not included.