4XW4

X-ray structure of PKAc with AMPPNP, SP20, calcium ions

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	cAMP-dependent protein kinase catalytic subunit alpha	polymer	356	41566.2	1	UniProt (P05132) Pfam (PF00069)	Mus musculus (Mouse)	PKA C-alpha
2	B (B)	cAMP-dependent protein kinase inhibitor alpha	polymer	20	2199.4	1	UniProt (by SIFTS) (P61926)	Oryctolagus cuniculus	PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform
3	C, D (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4	E (A)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
5	F, G (A, B)	water	water		18.0	343	Chemie (HOH)

Sequence modifications

A: 14 - 350 (UniProt: P05132)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Gly 1	-	expression tag
Asn 2	-	expression tag
Ala 3	-	expression tag
Ala 4	-	expression tag
Ala 5	-	expression tag
Ala 6	-	expression tag
Lys 7	-	expression tag
Lys 8	-	expression tag
Gly 9	-	expression tag
Ser 10	-	expression tag
Glu 11	-	expression tag
Gln 12	-	expression tag
Glu 13	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43765.6
Non-Polymers*	Number of molecules	3
	Total formula weight	586.4
All*	Total formula weight	44351.9

*Water molecules are not included.