4XV2
B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 292 | 33293.1 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B | Dabrafenib | non-polymer | 519.6 | 2 | Chemie (P06) | |||
3 | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B: 444 - 705 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Met 432 | - | expression tag |
Lys 433 | - | expression tag |
Lys 434 | - | expression tag |
Gly 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
His 441 | - | expression tag |
Gly 442 | - | expression tag |
Ser 443 | - | expression tag |
Ala 446 | Ser 446 | engineered mutation |
Ala 447 | Ser 447 | engineered mutation |
Ala 543 | Ile 543 | engineered mutation |
Ser 544 | Ile 544 | engineered mutation |
Lys 551 | Ile 551 | engineered mutation |
Arg 562 | Gln 562 | engineered mutation |
Asn 588 | Leu 588 | engineered mutation |
Glu 600 | Val 600 | engineered mutation |
Ser 630 | Lys 630 | engineered mutation |
Glu 667 | Phe 667 | engineered mutation |
Ser 673 | Tyr 673 | engineered mutation |
Arg 688 | Ala 688 | engineered mutation |
Ser 706 | - | expression tag |
Phe 707 | - | expression tag |
Pro 708 | - | expression tag |
Arg 709 | - | expression tag |
Ile 710 | - | expression tag |
Leu 711 | - | expression tag |
Ala 712 | - | expression tag |
Glu 713 | - | expression tag |
Ile 714 | - | expression tag |
Glu 715 | - | expression tag |
Glu 716 | - | expression tag |
Leu 717 | - | expression tag |
Ala 718 | - | expression tag |
Arg 719 | - | expression tag |
Glu 720 | - | expression tag |
Leu 721 | - | expression tag |
Ser 722 | - | expression tag |
Gly 723 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66586.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1039.1 | |
All* | Total formula weight | 67625.4 |