4XV1
B-Raf Kinase V600E oncogenic mutant in complex with PLX7904
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 292 | 33293.1 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | A | N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide | non-polymer | 512.5 | 1 | Chemie (904) | |||
| 3 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 444 - 705 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Met 432 | - | expression tag |
| Lys 433 | - | expression tag |
| Lys 434 | - | expression tag |
| Gly 435 | - | expression tag |
| His 436 | - | expression tag |
| His 437 | - | expression tag |
| His 438 | - | expression tag |
| His 439 | - | expression tag |
| His 440 | - | expression tag |
| His 441 | - | expression tag |
| Gly 442 | - | expression tag |
| Ser 443 | - | expression tag |
| Ala 446 | Ser 446 | engineered mutation |
| Ala 447 | Ser 447 | engineered mutation |
| Ala 543 | Ile 543 | engineered mutation |
| Ser 544 | Ile 544 | engineered mutation |
| Lys 551 | Ile 551 | engineered mutation |
| Arg 562 | Gln 562 | engineered mutation |
| Asn 588 | Leu 588 | engineered mutation |
| Glu 600 | Val 600 | engineered mutation |
| Ser 630 | Lys 630 | engineered mutation |
| Glu 667 | Phe 667 | engineered mutation |
| Ser 673 | Tyr 673 | engineered mutation |
| Arg 688 | Ala 688 | engineered mutation |
| Ser 706 | - | expression tag |
| Phe 707 | - | expression tag |
| Pro 708 | - | expression tag |
| Arg 709 | - | expression tag |
| Ile 710 | - | expression tag |
| Leu 711 | - | expression tag |
| Ala 712 | - | expression tag |
| Glu 713 | - | expression tag |
| Ile 714 | - | expression tag |
| Glu 715 | - | expression tag |
| Glu 716 | - | expression tag |
| Leu 717 | - | expression tag |
| Ala 718 | - | expression tag |
| Arg 719 | - | expression tag |
| Glu 720 | - | expression tag |
| Leu 721 | - | expression tag |
| Ser 722 | - | expression tag |
| Gly 723 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66586.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 512.5 | |
| All* | Total formula weight | 67098.8 |
