4XT1
Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | G-protein coupled receptor homolog US28 | polymer | 362 | 42041.1 | 1 | UniProt (P69332) Pfam (PF00001) In PDB | Cytomegalovirus | HHRF3 |
2 | B | Fractalkine | polymer | 91 | 9970.5 | 1 | UniProt (P78423) Pfam (PF00048) In PDB | Homo sapiens (Human) | C-X3-C motif chemokine 1,CX3C membrane-anchored chemokine,Neurotactin,Small-inducible cytokine D1 |
3 | C | nanobody 7 | polymer | 134 | 14624.2 | 1 | Vicugna pacos | ||
4 | A | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
5 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 6 | Chemie (OLC) | |||
6 | A | UNKNOWN LIGAND | non-polymer | 7 | Chemie (UNL) | ||||
7 | A | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) | |||
8 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 1 - 354 (UniProt: P69332)
B: 1 - 77 (UniProt: P78423)
PDB | External Database | Details |
---|---|---|
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Ala 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 9 | Asn 33 | engineered mutation |
Ser 78 | - | expression tag |
Gly 79 | - | expression tag |
Ser 80 | - | expression tag |
Gly 81 | - | expression tag |
Ser 82 | - | expression tag |
Ala 83 | - | expression tag |
Ala 84 | - | expression tag |
Ala 85 | - | expression tag |
Leu 86 | - | expression tag |
Glu 87 | - | expression tag |
Val 88 | - | expression tag |
Leu 89 | - | expression tag |
Phe 90 | - | expression tag |
Gln 91 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 66635.7 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 3030.6 | |
All* | Total formula weight | 69666.4 |