4XT1
Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G-protein coupled receptor homolog US28 | polymer | 362 | 42041.1 | 1 | UniProt (P69332) | Cytomegalovirus | HHRF3 |
| 2 | B (B) | Fractalkine | polymer | 91 | 9970.5 | 1 | UniProt (P78423) Pfam (PF00048) | Homo sapiens (Human) | C-X3-C motif chemokine 1,CX3C membrane-anchored chemokine,Neurotactin,Small-inducible cytokine D1 |
| 3 | C (C) | nanobody 7 | polymer | 134 | 14624.2 | 1 | Vicugna pacos | ||
| 4 | D, E (A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (18640088) PubChem (1715243) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (1715244) PubChem (23423981) PubChem (45044259) PubChem (638019) PubChem (49853509) PubChem (50990013) PubChem (44654663) PubChem (52934537) PubChem (56621683) PubChem (1549081) PubChem (1553803) PubChem (46937002) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (59274407) PubChem (5283629) PubChem (5284644) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (5315842) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (6419195) PubChem (5997) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (1551269) PubChem (90070115) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (117965027) PubChem (6432564) PubChem (101624109) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (138967089) PubChem (139566851) PubChem (130459183) PubChem (131992107) PubChem (15939944) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (171828367) PubChem (173516975) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 5 | F, G, H, I, J... (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 6 | Chemie (OLC) PubChem (25021708) PubChem (46840179) PubChem (54294271) PubChem (54294270) PubChem (5283468) PubChem (5364833) PubChem (33022) PubChem (11451146) PubChem (12178130) | |||
| 6 | L, M, N, O, P... (A) | UNKNOWN LIGAND | non-polymer | 7 | Chemie (UNL) | ||||
| 7 | S (A) | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) PubChem (1110) | |||
| 8 | T, U, V (A, B, C) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 1 - 354 (UniProt: P69332)
B: 1 - 77 (UniProt: P78423)
| PDB | External Database | Details |
|---|---|---|
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Ala 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 9 | Asn 33 | engineered mutation |
| Ser 78 | - | expression tag |
| Gly 79 | - | expression tag |
| Ser 80 | - | expression tag |
| Gly 81 | - | expression tag |
| Ser 82 | - | expression tag |
| Ala 83 | - | expression tag |
| Ala 84 | - | expression tag |
| Ala 85 | - | expression tag |
| Leu 86 | - | expression tag |
| Glu 87 | - | expression tag |
| Val 88 | - | expression tag |
| Leu 89 | - | expression tag |
| Phe 90 | - | expression tag |
| Gln 91 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 66635.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3030.6 | |
| All* | Total formula weight | 69666.4 |
