4XPN

Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GADD34

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	299	34162.1	2	UniProt (P62136) Pfam (PF16891) Pfam (PF00149)	Homo sapiens (Human)	PP-1A
2	B, D (B, D)	Protein phosphatase 1 regulatory subunit 15A	polymer	43	4941.7	2	UniProt (O75807) Pfam (PF10488)	Homo sapiens (Human)	Growth arrest and DNA damage-inducible protein GADD34,Myeloid differentiation primary response protein MyD116 homolog
3	E, F, I, J (A, C)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
4	G, K (A, C)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
5	H, L (A, C)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	M, N, O, P (A, B, C, D)	water	water		18.0	223	Chemie (HOH)

Sequence modifications

A, C: 7 - 300 (UniProt: P62136)

PDB	External Database	Details
Gly 2	-	expression tag
His 3	-	expression tag
Met 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag

B, D: 552 - 591 (UniProt: O75807)

PDB	External Database	Details
Gly 549	-	expression tag
His 550	-	expression tag
Met 551	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	78207.7
Non-Polymers*	Number of molecules	8
	Total formula weight	593.9
All*	Total formula weight	78801.6

*Water molecules are not included.