4XMP

Crystal structure of broadly and potently neutralizing antibody VRC08 in complex with HIV-1 clade A strain Q842.d12 gp120

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (G)	Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160	polymer	354	39667.8	1	UniProt (Q8JDI3) Pfam (PF00516)	Human immunodeficiency virus 1
2	B (H)	HEAVY CHAIN OF ANTIBODY VRC08	polymer	235	25258.6	1	Pfam (PF07654) UniProt (by SIFTS) (P01857)	Homo sapiens (Human)
3	C (L)	LIGHT CHAIN OF ANTIBODY VRC08	polymer	211	23009.8	1	Pfam (PF07654) UniProt (by SIFTS) (P01834)	Homo sapiens (Human)
4	D, E, F, G, H... (G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)
5	O, P (G)	(R,R)-2,3-BUTANEDIOL	non-polymer		90.1	2	Chemie (BU3)
6	Q, R, S (G, H, L)	water	water		18.0	628	Chemie (HOH)

Sequence modifications

G: 44 - 123 (UniProt: Q8JDI3)
G: 199 - 317 (UniProt: Q8JDI3)

PDB	External Database	Details
Gly 124	-	linker
Gly 198	-	linker

G: 324 - 492 (UniProt: Q8JDI3)

PDB	External Database	Details
Gly 318	-	linker
Gly 319	-	linker
Ser 320	-	linker
Gly 321	-	linker
Ser 322	-	linker
Gly 323	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	87936.2
Non-Polymers*	Number of molecules	13
	Total formula weight	2613.5
All*	Total formula weight	90549.7

*Water molecules are not included.