4XHS
Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Maltose-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 12 | polymer | 480 | 52777.8 | 2 | UniProt (P0AEY0) UniProt (P59046) Pfam (PF01547) UniProt (by SIFTS) (P0AEX9) In PDB | Escherichia coli O157:H7 | MBP,MMBP,Maltodextrin-binding protein,Monarch-1,PYRIN-containing APAF1-like protein 7,Regulated by nitric oxide |
2 | C, D | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
3 | A, B | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
4 | A, B | SODIUM ION | non-polymer | 23.0 | 7 | Chemie (NA) | |||
5 | water | water | 18.0 | 1081 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 367 (UniProt: P0AEY0)
A, B: 377 - 473 (UniProt: P59046)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ala 83 | Asp 108 | conflict |
Ala 84 | Lys 109 | conflict |
Ala 173 | Glu 198 | conflict |
Ala 174 | Asn 199 | conflict |
Ala 240 | Lys 265 | conflict |
Ala 360 | Glu 385 | conflict |
Ala 363 | Lys 388 | conflict |
Ala 364 | Asp 389 | conflict |
Asn 368 | - | linker |
Ala 369 | - | linker |
Ala 370 | - | linker |
Arg 371 | - | linker |
Ala 372 | - | linker |
Phe 373 | - | linker |
Ala 374 | - | linker |
Ala 375 | - | linker |
Ala 376 | - | linker |
PDB | External Database | Details |
---|---|---|
Glu 474 | - | expression tag |
His 475 | - | expression tag |
His 476 | - | expression tag |
His 477 | - | expression tag |
His 478 | - | expression tag |
His 479 | - | expression tag |
His 480 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 105555.6 | |
Branched | Number of molecules | 2 |
Total formula weight | 684.6 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 345.0 | |
All* | Total formula weight | 106585.2 |