4XEY

Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Tyrosine-protein kinase ABL1	polymer	408	46860.0	2	UniProt (P00519) Pfam (PF00017) Pfam (PF07714)	Homo sapiens (Human)	Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150
2	C, D (B, A)	N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE	non-polymer		488.0	2	Chemie (1N1)

Sequence modifications

B, A: 138 - 534 (UniProt: P00519)

PDB	External Database	Details
Met 135	-	expression tag
Ala 136	-	expression tag
Ser 137	-	expression tag
Leu 535	-	expression tag
Glu 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
His 541	-	expression tag
His 542	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	93720.0
Non-Polymers*	Number of molecules	2
	Total formula weight	976.0
All*	Total formula weight	94696.0

*Water molecules are not included.