4XEY
Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Tyrosine-protein kinase ABL1 | polymer | 408 | 46860.0 | 2 | UniProt (P00519) Pfam (PF00017) Pfam (PF07714) In PDB | Homo sapiens (Human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
2 | B, A | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 2 | Chemie (1N1) |
Sequence modifications
B, A: 138 - 534 (UniProt: P00519)
PDB | External Database | Details |
---|---|---|
Met 135 | - | expression tag |
Ala 136 | - | expression tag |
Ser 137 | - | expression tag |
Leu 535 | - | expression tag |
Glu 536 | - | expression tag |
His 537 | - | expression tag |
His 538 | - | expression tag |
His 539 | - | expression tag |
His 540 | - | expression tag |
His 541 | - | expression tag |
His 542 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 93720.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 976.0 | |
All* | Total formula weight | 94696.0 |