4XEO
Crystal Structure of human AlaRS catalytic domain with R329H mutation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Alanine--tRNA ligase, cytoplasmic | polymer | 475 | 53295.1 | 2 | UniProt (P49588) Pfam (PF01411) In PDB | Homo sapiens (Human) | Alanyl-tRNA synthetase,AlaRS,Renal carcinoma antigen NY-REN-42 |
2 | A, B | '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE | non-polymer | 417.4 | 2 | Chemie (A5A) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
5 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | water | water | 18.0 | 810 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 455 (UniProt: P49588)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
His 329 | Arg 329 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 106590.3 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1636.0 | |
All* | Total formula weight | 108226.3 |