4XEE
Structure of active-like neurotensin receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neurotensin receptor type 1, Endolysin chimera | polymer | 541 | 60743.8 | 1 | UniProt (P20789) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) | Rattus norvegicus (Rat) | NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH,Lysis protein, Lysozyme, Muramidase |
| 2 | B (B) | Neurotensin/neuromedin N | polymer | 6 | 819.0 | 1 | UniProt (P20068) | Rattus norvegicus | |
| 3 | C, D (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 2 | Chemie (1PE) | |||
| 4 | E (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 5 | F (A) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 6 | G (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | H (A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 43 - 988 (UniProt: P20789)
A: 1002 - 1161 (UniProt: P00720)
| PDB | External Database | Details |
|---|---|---|
| Asp 33 | - | expression tag |
| Tyr 34 | - | expression tag |
| Lys 35 | - | expression tag |
| Asp 36 | - | expression tag |
| Asp 37 | - | expression tag |
| Asp 38 | - | expression tag |
| Asp 39 | - | expression tag |
| Ala 40 | - | expression tag |
| Thr 41 | - | expression tag |
| Ser 42 | - | expression tag |
| Leu 86 | Ala 86 | engineered mutation |
| Ala 215 | Gly 215 | engineered mutation |
| Ala 360 | Val 360 | engineered mutation |
| Ala 989 | - | linker |
| His 990 | - | linker |
| His 991 | - | linker |
| His 992 | - | linker |
| His 993 | - | linker |
| His 994 | - | linker |
| His 995 | - | linker |
| His 996 | - | linker |
| His 997 | - | linker |
| His 998 | - | linker |
| His 999 | - | linker |
| Gly 1000 | - | linker |
| Gly 1001 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 1012 | Arg 12 | conflict |
| Thr 1054 | Cys 54 | conflict |
| Ala 1097 | Cys 97 | conflict |
| Asn 1122 | Gln 122 | conflict |
| Asn 1123 | Gln 123 | conflict |
| Arg 1137 | Ile 137 | conflict |
| Gly 1162 | - | expression tag |
| Ser 1163 | - | expression tag |
| Gly 1164 | - | expression tag |
| Ser 1165 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61562.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1010.1 | |
| All* | Total formula weight | 62572.9 |
