4XE6
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1061)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | X | Dihydrofolate reductase | polymer | 160 | 18389.0 | 1 | UniProt (P0A017) Pfam (PF00186) In PDB | Staphylococcus aureus | DHFR |
| 2 | X | 6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | non-polymer | 373.5 | 1 | Chemie (06U) | |||
| 3 | X | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | X | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 5 | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
X: 0 - 156 (UniProt: P0A017)
| PDB | External Database | Details |
|---|---|---|
| Lys 157 | - | expression tag |
| Leu 158 | - | expression tag |
| Glu 159 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18389.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1177.9 | |
| All* | Total formula weight | 19566.9 |
