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4XDL

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Potassium channel subfamily K member 10polymer28231060.14UniProt (P57789)
Pfam (PF00520)
Pfam (PF07885)
Homo sapiens (Human)Outward rectifying potassium channel protein TREK-2,TREK-2 K(+) channel subunit
2E, F, K, M, N...
(A, B, C)
POTASSIUM IONnon-polymer39.16Chemie (K)
3G, J, R, S
(A, D)
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer790.14Chemie (PC1)
4H, Q
(A, D)
CADMIUM IONnon-polymer112.42Chemie (CD)
5I, L, P, T
(A, B, C, D)
3-[2-bromanyl-4-(trifluoromethyl)phenoxy]-N-methyl-3-phenyl-propan-1-aminenon-polymer388.24Chemie (40D)
Sequence modifications
A, B, C, D: 67 - 340 (UniProt: P57789)
PDBExternal DatabaseDetails
Met 66-initiating methionine
Ala 341-expression tag
Glu 342-expression tag
Asn 343-expression tag
Leu 344-expression tag
Tyr 345-expression tag
Phe 346-expression tag
Gln 347-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight124240.4
Non-Polymers*Number of molecules16
Total formula weight5172.9
All*Total formula weight129413.3
*Water molecules are not included.

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PDB entries from 2025-07-09

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