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4XCB

Crystal Structure of HygX from Streptomyces hygroscopicus with nickel, 2-oxoglutarate, and hygromycin B bound

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
oxidase/hydroxylasepolymer26129364.04UniProt (Q2MFS1)
Pfam (PF05721)
Streptomyces hygroscopicus subsp. hygroscopicus
2E, H, K, N
(A, B, C, D)
NICKEL (II) IONnon-polymer58.74Chemie (NI)
3F, I, L, O
(A, B, C, D)
2-OXOGLUTARIC ACIDnon-polymer146.14Chemie (AKG)
4G, J, M, P
(A, B, C, D)
HYGROMYCIN B VARIANTnon-polymer527.54Chemie (HY0)
5Q, R, S, T
(A, B, C, D)
waterwater18.0578Chemie (HOH)
Sequence modifications
A, B, C, D: 2 - 258 (UniProt: Q2MFS1)
PDBExternal DatabaseDetails
Leu -2-expression tag
His -1-expression tag
Met 0-expression tag
Val 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight117455.9
Non-Polymers*Number of molecules12
Total formula weight2929.2
All*Total formula weight120385.1
*Water molecules are not included.

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PDB entries from 2025-06-18

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