4X6P
FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Coagulation factor XI, light chain | polymer | 238 | 26856.5 | 2 | UniProt (P03951) Pfam (PF00089) In PDB | Homo sapiens (Human) | FXI,Plasma thromboplastin antecedent,PTA |
| 2 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | A, B | (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide | non-polymer | 551.0 | 2 | Chemie (3YU) | |||
| 4 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 5 | A, B | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 245 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53713.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2289.1 | |
| All* | Total formula weight | 56002.1 |
