4X5Z
menin in complex with MI-136
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Menin | polymer | 489 | 54570.2 | 1 | UniProt (O00255) Pfam (PF05053) In PDB | Homo sapiens (Human) | |
2 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A | 5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile | non-polymer | 470.5 | 1 | Chemie (3XY) | |||
4 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
5 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
7 | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A: 1 - 459 (UniProt: O00255)
A: 537 - 593 (UniProt: O00255)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
- | Ile 54 | deletion |
- | Pro 55 | deletion |
- | Thr 56 | deletion |
- | Asn 57 | deletion |
- | Val 58 | deletion |
- | Pro 59 | deletion |
- | Glu 60 | deletion |
- | Leu 61 | deletion |
- | Thr 62 | deletion |
- | Phe 63 | deletion |
- | Gln 64 | deletion |
- | Pro 65 | deletion |
- | Ser 66 | deletion |
- | Pro 67 | deletion |
- | Ala 68 | deletion |
- | Pro 69 | deletion |
- | Asp 70 | deletion |
- | Pro 71 | deletion |
- | Pro 72 | deletion |
- | Gly 73 | deletion |
- | Glu 387 | deletion |
- | Glu 388 | deletion |
- | Arg 389 | deletion |
- | Pro 390 | deletion |
- | Gly 391 | deletion |
- | Glu 392 | deletion |
- | Gln 393 | deletion |
- | Ser 394 | deletion |
- | Gln 395 | deletion |
- | Gly 396 | deletion |
- | Thr 397 | deletion |
- | Gln 398 | deletion |
Pro 428 | Pro 428 | linker |
Thr 429 | Thr 429 | linker |
Pro 430 | Pro 430 | linker |
Val 431 | Val 431 | linker |
Leu 432 | Leu 432 | linker |
His 433 | His 433 | linker |
Val 434 | Val 434 | linker |
Gly 435 | Gly 435 | linker |
Trp 436 | Trp 436 | linker |
Ala 437 | Ala 437 | linker |
Thr 438 | Thr 438 | linker |
Phe 439 | Phe 439 | linker |
Leu 440 | Leu 440 | linker |
Val 441 | Val 441 | linker |
Gln 442 | Gln 442 | linker |
Ser 443 | Ser 443 | linker |
Leu 444 | Leu 444 | linker |
Gly 445 | Gly 445 | linker |
Arg 446 | Arg 446 | linker |
Phe 447 | Phe 447 | linker |
Glu 448 | Glu 448 | linker |
Gly 449 | Gly 449 | linker |
Gln 450 | Gln 450 | linker |
Val 451 | Val 451 | linker |
Arg 452 | Arg 452 | linker |
Gln 453 | Gln 453 | linker |
Lys 454 | Lys 454 | linker |
Val 455 | Val 455 | linker |
Arg 456 | Arg 456 | linker |
Ile 457 | Ile 457 | linker |
Val 458 | Val 458 | linker |
Ser 459 | Ser 459 | linker |
PDB | External Database | Details |
---|---|---|
Ala 541 | Thr 541 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54570.2 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1267.3 | |
All* | Total formula weight | 55837.5 |