4X5E

Anthranilate phosphoribosyltransferase variant R194A from Mycobacterium tuberculosis with pyrophosphate, Mg2+ and anthranilate bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Anthranilate phosphoribosyltransferase	polymer	378	38762.8	2	UniProt (A5U4M0) Pfam (PF02885) Pfam (PF00591) UniProt (by SIFTS) (P9WFX5)	Mycobacterium tuberculosis
2	C, J (A, B)	PYROPHOSPHATE 2-	non-polymer		176.0	2	Chemie (POP)
3	D, E, K, L (A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	F, G, M, N (A, B)	2-AMINOBENZOIC ACID	non-polymer		137.1	4	Chemie (BE2)
5	H, I, O, P, Q (A, B)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
6	R, S (A, B)	water	water		18.0	520	Chemie (HOH)

Sequence modifications

A, B: 1 - 370 (UniProt: A5U4M0)

PDB	External Database	Details
Ala 194	Arg 194	engineered mutation
Leu 371	-	expression tag
Glu 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77525.5
Non-Polymers*	Number of molecules	15
	Total formula weight	1458.2
All*	Total formula weight	78983.7

*Water molecules are not included.