4X5B

Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis in complex with PRPP and Mg

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Anthranilate phosphoribosyltransferase	polymer	378	38804.8	2	UniProt (A5U4M0) Pfam (PF02885) Pfam (PF00591) UniProt (by SIFTS) (P9WFX5)	Mycobacterium tuberculosis
2	C, D (A, B)	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	2	Chemie (PRP)
3	E, F (B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	G, H (A, B)	water	water		18.0	46	Chemie (HOH)

Sequence modifications

A, B: 1 - 370 (UniProt: A5U4M0)

PDB	External Database	Details
Leu 193	Arg 193	engineered mutation
Leu 371	-	expression tag
Glu 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77609.7
Non-Polymers*	Number of molecules	4
	Total formula weight	828.8
All*	Total formula weight	78438.4

*Water molecules are not included.