4X59

Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Anthranilate phosphoribosyltransferase	polymer	378	38822.8	2	UniProt (A5U4M0) Pfam (PF02885) Pfam (PF00591) UniProt (by SIFTS) (P9WFX5) In PDB	Mycobacterium tuberculosis
2	A, B	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	2	Chemie (PRP)
3	A, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
4	B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	B	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)
6		water	water		18.0	236	Chemie (HOH)

Sequence modifications

A, B: 1 - 370 (UniProt: A5U4M0)

PDB	External Database	Details
Ala 180	Pro 180	engineered mutation
Leu 371	-	expression tag
Glu 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77645.7
Non-Polymers*	Number of molecules	12
	Total formula weight	1519.5
All*	Total formula weight	79165.2

*Water molecules are not included.