4WY6
Crystal structure of human BACE-1 bound to Compound 36
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-secretase 1 | polymer | 415 | 46441.0 | 1 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
2 | A | (4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(fluoromethyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine | non-polymer | 316.3 | 1 | Chemie (3VP) | |||
3 | A | IODIDE ION | non-polymer | 126.9 | 5 | Chemie (IOD) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
5 | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence modifications
A: -15 - 393 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
His 394 | - | expression tag |
His 395 | - | expression tag |
His 396 | - | expression tag |
His 397 | - | expression tag |
His 398 | - | expression tag |
His 399 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 46441.0 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1263.4 | |
All* | Total formula weight | 47704.4 |