4WY1

Crystal structure of human BACE-1 bound to Compound 24B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Beta-secretase 1	polymer	404	45156.7	1	UniProt (P56817) Pfam (PF00026) In PDB	Homo sapiens (Human)	Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2
2	A	(4aR,8aS)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine	non-polymer		284.3	1	Chemie (3VO)
3		water	water		18.0	380	Chemie (HOH)

Sequence modifications

A: -3 - 392 (UniProt: P56817)

PDB	External Database	Details
Arg 393	-	expression tag
Ser 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
His 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
His 400	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45156.7
Non-Polymers*	Number of molecules	1
	Total formula weight	284.3
All*	Total formula weight	45441.1

*Water molecules are not included.