4WY1
Crystal structure of human BACE-1 bound to Compound 24B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-secretase 1 | polymer | 404 | 45156.7 | 1 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
| 2 | B (A) | (4aR,8aS)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine | non-polymer | 284.3 | 1 | Chemie (3VO) | |||
| 3 | C (A) | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
A: -3 - 392 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Arg 393 | - | expression tag |
| Ser 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45156.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 284.3 | |
| All* | Total formula weight | 45441.1 |
