4WWO
Crystal structure of human PI3K-gamma in complex with phenylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 959 | 109767.0 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase subunit gamma,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma,p110gamma,Phosphoinositide-3-kinase catalytic gamma polypeptide,Serine/threonine protein kinase PIK3CG,p120-PI3K |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | A | N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine | non-polymer | 418.9 | 1 | Chemie (3VD) | |||
| 4 | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109767.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 803.1 | |
| All* | Total formula weight | 110570.1 |
