4WRM

Structure of the human CSF-1:CSF-1R complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Macrophage colony-stimulating factor 1 receptor	polymer	493	54721.5	1	UniProt (P07333) Pfam (PF00047) Pfam (PF13927)	Homo sapiens (Human)	CSF-1 receptor,M-CSF-R,Proto-oncogene c-Fms
2	B (B)	Macrophage colony-stimulating factor 1	polymer	170	19757.3	1	UniProt (P09603) Pfam (PF05337)	Homo sapiens (Human)	MCSF,Lanimostim

Sequence modifications

A: 20 - 504 (UniProt: P07333)

PDB	External Database	Details
Thr 505	-	expression tag
Lys 506	-	expression tag
His 507	-	expression tag
His 508	-	expression tag
His 509	-	expression tag
His 510	-	expression tag
His 511	-	expression tag
His 512	-	expression tag

B: 1 - 149 (UniProt: P09603)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74478.8
All*	Total formula weight	74478.8

*Water molecules are not included.