4WRF
Crystal Structure of Surfactant Protein-A DEDN Mutant (E171D/P175E/R197N/K203D) Complexed with Mannose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pulmonary surfactant-associated protein A | polymer | 148 | 16633.4 | 1 | UniProt (P08427) Pfam (PF00059) | Rattus norvegicus (Rat) | SP-A |
| 2 | B, C, D (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 3 | E (A) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) | |||
| 4 | F (A) | HEXANE-1,6-DIOL | non-polymer | 118.2 | 1 | Chemie (HEZ) | |||
| 5 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | H (A) | water | water | 18.0 | 109 | Chemie (HOH) |
Sequence modifications
A: 81 - 228 (UniProt: P08427)
| PDB | External Database | Details |
|---|---|---|
| Asp 171 | Glu 191 | engineered mutation |
| Glu 175 | Pro 195 | engineered mutation |
| Ser 187 | Asn 207 | engineered mutation |
| Asn 197 | Arg 217 | engineered mutation |
| Asp 203 | Lys 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16633.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 454.0 | |
| All* | Total formula weight | 17087.4 |
