4WNV
Human Cytochrome P450 2D6 Quinine Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 2D6 | polymer | 479 | 53730.6 | 4 | UniProt (P10635) Pfam (PF00067) | Homo sapiens (Human) | CYPIID6,Cytochrome P450-DB1,Debrisoquine 4-hydroxylase |
| 2 | E, L, R, X (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, M, S, Y (A, B, C, D) | Quinine | non-polymer | 324.4 | 4 | Chemie (QI9) PubChem (16759993) PubChem (5769) PubChem (5953) PubChem (8549) PubChem (21862291) PubChem (13120) PubChem (25522) PubChem (22770772) PubChem (71795) PubChem (94175) PubChem (23616571) PubChem (24096961) PubChem (24867865) PubChem (441073) PubChem (441074) PubChem (44630461) PubChem (637552) PubChem (3036746) PubChem (667448) PubChem (667449) PubChem (45050619) PubChem (45934355) PubChem (57497484) PubChem (57647726) PubChem (59082714) PubChem (59091406) PubChem (3032576) PubChem (3034034) PubChem (2728270) PubChem (5317111) PubChem (5317112) PubChem (5320867) PubChem (5320868) PubChem (68007244) PubChem (5484444) PubChem (5484450) PubChem (3000825) PubChem (73950789) PubChem (3003191) PubChem (1065) PubChem (6328027) PubChem (6453100) PubChem (6602154) PubChem (6604605) PubChem (6916033) PubChem (6916036) PubChem (7048767) PubChem (9967055) PubChem (12309515) PubChem (12309517) PubChem (12309518) PubChem (12309519) PubChem (12309520) PubChem (91971361) PubChem (5748152) PubChem (102016704) PubChem (6857801) PubChem (102600842) PubChem (10448938) PubChem (117841973) PubChem (129700770) PubChem (14822542) PubChem (160310226) PubChem (169722712) | |||
| 4 | G, H, N, O, T... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) PubChem (753) | |||
| 5 | AA, I, J, K, P... (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
| 6 | BA, Q (D, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 7 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 296 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 48 - 497 (UniProt: P10635)
| PDB | External Database | Details |
|---|---|---|
| Met 23 | - | initiating methionine |
| Ala 24 | - | expression tag |
| Lys 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Thr 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Lys 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Lys 32 | - | expression tag |
| Leu 33 | - | expression tag |
| Pro 34 | - | expression tag |
| Pro 35 | - | expression tag |
| Gly 36 | - | expression tag |
| Pro 37 | - | expression tag |
| Leu 38 | - | expression tag |
| Pro 39 | - | expression tag |
| Leu 40 | - | expression tag |
| Pro 41 | - | expression tag |
| Gly 42 | - | expression tag |
| Leu 43 | - | expression tag |
| Gly 44 | - | expression tag |
| Asn 45 | - | expression tag |
| Leu 46 | - | expression tag |
| Leu 47 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 214922.3 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 4912.1 | |
| All* | Total formula weight | 219834.4 |
