4WNG

Crystal structure of the TPR domain of LGN in complex with Frmpd4/Preso1 at 2.1 Angstrom resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	G-protein-signaling modulator 2	polymer	407	45061.4	1	UniProt (P81274) Pfam (PF13374) Pfam (PF13176) Pfam (PF13181)	Homo sapiens (Human)	Mosaic protein LGN
2	B (B)	FERM and PDZ domain-containing protein 4	polymer	60	6823.6	1	UniProt (Q14CM0)	Homo sapiens (Human)	PDZ domain-containing protein 10,PSD-95-interacting regulator of spine morphogenesis,Preso
3	C, D (A, B)	water	water		18.0	62	Chemie (HOH)

Sequence modifications

A: 13 - 414 (UniProt: P81274)

PDB	External Database	Details
Gly 8	-	expression tag
Pro 9	-	expression tag
Leu 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag

B: 978 - 1025 (UniProt: Q14CM0)

PDB	External Database	Details
Gly 974	-	expression tag
Pro 975	-	expression tag
Gly 976	-	expression tag
Ser 977	-	expression tag
Glu 1026	-	expression tag
Phe 1027	-	expression tag
His 1028	-	expression tag
His 1029	-	expression tag
His 1030	-	expression tag
His 1031	-	expression tag
His 1032	-	expression tag
His 1033	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51885.1
All*	Total formula weight	51885.1

*Water molecules are not included.