4WLU

Crystal structure of L-malate and NAD bound MDH2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Malate dehydrogenase, mitochondrial	polymer	340	35855.4	4	UniProt (P40926) Pfam (PF00056) Pfam (PF02866)	Homo sapiens (Human)
2	E, G, I, K (A, B, C, D)	(2S)-2-hydroxybutanedioic acid	non-polymer		134.1	4	Chemie (LMR)
3	F, H, J, L (A, B, C, D)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
4	M, N, O, P (A, B, C, D)	water	water		18.0	102	Chemie (HOH)

Sequence modifications

A, B, C, D: 20 - 338 (UniProt: P40926)

PDB	External Database	Details
Met -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Ser 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Ser 9	-	expression tag
Ser 10	-	expression tag
Gly 11	-	expression tag
Leu 12	-	expression tag
Val 13	-	expression tag
Pro 14	-	expression tag
Arg 15	-	expression tag
Gly 16	-	expression tag
Ser 17	-	expression tag
His 18	-	expression tag
Met 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	143421.7
Non-Polymers*	Number of molecules	8
	Total formula weight	3190.0
All*	Total formula weight	146611.8

*Water molecules are not included.