4WKN

Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Aminodeoxyfutalosine nucleosidase	polymer	245	26886.9	1	UniProt (Q9ZMY2) Pfam (PF01048)	Helicobacter pylori	Aminofutalosine nucleosidase,5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase,MTAN,6-amino-6-deoxyfutalosine N-ribosylhydrolase
2	B (A)	(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL	non-polymer		293.4	1	Chemie (TDI)
3	C (A)	water	water		18.0	149	Chemie (HOH)

Sequence modifications

A: 2 - 230 (UniProt: Q9ZMY2)

PDB	External Database	Details
Met -14	-	initiating methionine
Gly -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Val 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	26886.9
Non-Polymers*	Number of molecules	1
	Total formula weight	293.4
All*	Total formula weight	27180.3

*Water molecules are not included.