4WK2
Metal Ion and Ligand Binding of Integrin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-5 | polymer | 452 | 48116.9 | 1 | UniProt (P08648) Pfam (PF01839) | Homo sapiens (Human) | CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5 |
| 2 | B (B) | Integrin beta-1 | polymer | 445 | 49502.9 | 1 | UniProt (P05556) Pfam (PF17205) Pfam (PF00362) | Homo sapiens (Human) | Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta |
| 3 | C (C) | GLY-ARG-GLY-ASP-SER-PRO | polymer | 6 | 588.6 | 1 | Homo sapiens | ||
| 4 | D (D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
| 5 | E, G, H, I (E, G, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (F) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 7 | J, K, L, M, P... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 8 | N, R, S, T (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 9 | O (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 10 | U, V (A, B) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 1 - 452 (UniProt: P08648)
B: 1 - 445 (UniProt: P05556)
| PDB | External Database | Details |
|---|---|---|
| Val 451 | Ile 492 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Thr 195 | Ser 215 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98208.3 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3681.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1149.6 | |
| All* | Total formula weight | 103039.3 |
