4WHZ
Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 10 | polymer | 385 | 44099.9 | 1 | UniProt (P53779) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 10,MAP kinase p49 3F12,Stress-activated protein kinase 1b,SAPK1b,Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3 |
| 2 | A | 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide | non-polymer | 490.9 | 1 | Chemie (3NL) | |||
| 3 | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44099.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 490.9 | |
| All* | Total formula weight | 44590.9 |
