4WB3
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a-desArg complement anaphylatoxin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Complement C5 | polymer | 78 | 8890.4 | 3 | UniProt (P06684) Pfam (PF01821) In PDB | Mus musculus (Mouse) | Hemolytic complement |
| 2 | D, E | mixed L-RNA/L-DNA aptamer NOX-D20 (40-MER) | polymer | 40 | 12956.7 | 2 | synthetic construct | ||
| 3 | A, C, D, E | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | B, D | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | D, E | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 373 | Chemie (HOH) |
Sequence modifications
A, B, C: 679 - 754 (UniProt: P06684)
| PDB | External Database | Details |
|---|---|---|
| Gly 677 | - | expression tag |
| Ala 678 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 52584.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 466.2 | |
| All* | Total formula weight | 53050.8 |
