4WA9
The crystal structure of human abl1 wild type kinase domain in complex with axitinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Tyrosine-protein kinase ABL1 | polymer | 286 | 33040.7 | 2 | UniProt (P00519) Pfam (PF07714) In PDB | Homo sapiens (Human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
2 | B, A | AXITINIB | non-polymer | 386.5 | 2 | Chemie (AXI) | |||
3 | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
B, A: 246 - 512 (UniProt: P00519)
PDB | External Database | Details |
---|---|---|
Gly 227 | - | expression tag |
Ser 228 | - | expression tag |
Ser 229 | - | expression tag |
Pro 230 | - | expression tag |
Asn 231 | - | expression tag |
Tyr 232 | - | expression tag |
Asp 233 | - | expression tag |
Lys 234 | - | expression tag |
Trp 235 | - | expression tag |
Glu 236 | - | expression tag |
Met 237 | - | expression tag |
Glu 238 | - | expression tag |
Arg 239 | - | expression tag |
Thr 240 | - | expression tag |
Asp 241 | - | expression tag |
Ile 242 | - | expression tag |
Thr 243 | - | expression tag |
Met 244 | - | expression tag |
Lys 245 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66081.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 772.9 | |
All* | Total formula weight | 66854.4 |