4W9W
Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BMP-2-inducible protein kinase | polymer | 306 | 34356.6 | 1 | UniProt (Q9NSY1) Pfam (PF00069) | Homo sapiens (Human) | BIKe |
| 2 | B, C (A) | 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | non-polymer | 362.4 | 2 | Chemie (YDJ) | |||
| 3 | D, E, F, G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | I (A) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A: 39 - 344 (UniProt: Q9NSY1)
| PDB | External Database | Details |
|---|---|---|
| Ala 320 | Lys 320 | engineered mutation |
| Ala 321 | Lys 321 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34356.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1035.2 | |
| All* | Total formula weight | 35391.8 |
