4W6E
Human Tankyrase 1 with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tankyrase-1 | polymer | 211 | 24227.5 | 1 | UniProt (O95271) Pfam (PF00644) | Homo sapiens (Human) | TANK1,ADP-ribosyltransferase diphtheria toxin-like 5,ARTD5,Poly [ADP-ribose] polymerase 5A,TNKS-1,TRF1-interacting ankyrin-related ADP-ribose polymerase,Tankyrase I |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 2-(4-{6-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-8-(hydroxymethyl)quinazolin-4(3H)-one | non-polymer | 455.6 | 1 | Chemie (3J5) | |||
| 4 | D (A) | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence modifications
A: 1106 - 1314 (UniProt: O95271)
| PDB | External Database | Details |
|---|---|---|
| Ser 1104 | - | expression tag |
| Met 1105 | - | expression tag |
| Ile 1266 | Met 1266 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24227.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 521.0 | |
| All* | Total formula weight | 24748.5 |
