4V8R

The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, I, Q, Y (AA, Aa, BA, Ba)	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA	polymer	559	60557.6	4	UniProt (P12612) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-ALPHA, CCT-ALPHA
2	B, J, R, Z (AB, Ab, BB, Bb)	T-COMPLEX PROTEIN 1 SUBUNIT BETA	polymer	527	57276.3	4	UniProt (P39076) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-BETA, CCT-BETA
3	AA, C, K, S (AD, Ad, BD, Bd)	T-COMPLEX PROTEIN 1 SUBUNIT DELTA	polymer	528	57740.4	4	UniProt (P39078) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-DELTA, CCT-DELTA
4	BA, D, L, T (AE, Ae, BE, Be)	T-COMPLEX PROTEIN 1 SUBUNIT EPSILON	polymer	562	61995.0	4	UniProt (P40413) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-EPSILON, CCT-EPSILON
5	CA, E, M, U (AG, Ag, BG, Bg)	T-COMPLEX PROTEIN 1 SUBUNIT GAMMA	polymer	590	64939.8	4	UniProt (P39077) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-GAMMA, CCT-GAMMA
6	DA, F, N, V (AH, Ah, BH, Bh)	T-COMPLEX PROTEIN 1 SUBUNIT ETA	polymer	550	59802.4	4	UniProt (P42943) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-ETA, CCT-ETA
7	EA, G, O, W (AQ, Aq, BQ, Bq)	T-COMPLEX PROTEIN 1 SUBUNIT THETA	polymer	568	61735.1	4	UniProt (P47079) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-THETA, CCT-THETA
8	FA, H, P, X (AZ, Az, BZ, Bz)	T-COMPLEX PROTEIN 1 SUBUNIT ZETA	polymer	546	59997.6	4	UniProt (P39079) Pfam (PF00118)	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)	TCP-1-ZETA, CCT-ZETA
9	AD, BB, CC, DD, EB... (Ba, AZ, BA, Bb, Aa...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	32	Chemie (ADP)
10	AC, BD, CB, DC, ED... (Az, Ba, AZ, BA, Bb...)	BERYLLIUM TRIFLUORIDE ION	non-polymer		66.0	32	Chemie (BEF)
11	AB, BC, CD, DB, EC... (AQ, Az, Ba, AZ, BA...)	MAGNESIUM ION	non-polymer		24.3	32	Chemie (MG)

Sequence modifications

AD, Ad, BD, Bd: 1 - 528 (UniProt: P39078)

PDB	External Database	Details
Asp 345	Gly 345	engineered mutation

AG, Ag, BG, Bg: 375 - 534 (UniProt: P39077)

PDB	External Database	Details
Gly 901	-	insertion
Ser 902	-	insertion
Gly 903	-	insertion
Ser 904	-	insertion
Gly 905	-	insertion
Trp 906	-	insertion
Ser 907	-	insertion
His 908	-	insertion
Pro 909	-	insertion
Gln 910	-	insertion
Phe 911	-	insertion
Glu 912	-	insertion
Lys 913	-	insertion
Gly 914	-	insertion
Ser 915	-	insertion
Gly 916	-	insertion
Lys 917	-	insertion
Arg 918	-	insertion
Arg 919	-	insertion
Trp 920	-	insertion
Lys 921	-	insertion
Lys 922	-	insertion
Asn 923	-	insertion
Phe 924	-	insertion
Ile 925	-	insertion
Ala 926	-	insertion
Val 927	-	insertion
Ser 928	-	insertion
Ala 929	-	insertion
Ala 930	-	insertion
Asn 931	-	insertion
Arg 932	-	insertion
Phe 933	-	insertion
Lys 934	-	insertion
Lys 935	-	insertion
Ile 936	-	insertion
Ser 937	-	insertion
Ser 938	-	insertion
Ser 939	-	insertion
Gly 940	-	insertion
Ala 941	-	insertion
Leu 942	-	insertion
Gly 943	-	insertion
Ser 944	-	insertion
Gly 945	-	insertion
His 946	-	insertion
His 947	-	insertion
His 948	-	insertion
His 949	-	insertion
His 950	-	insertion
His 951	-	insertion
His 952	-	insertion
His 953	-	insertion
Gly 954	-	insertion
Ser 955	-	insertion
Gly 956	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	32
	Total formula weight	1936176.8
Non-Polymers*	Number of molecules	96
	Total formula weight	16560.4
All*	Total formula weight	1952737.2

*Water molecules are not included.