4UZL

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I MYRISTOLEATE COMPLEX - 2.1A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PROTEIN NOTUM HOMOLOG	polymer	386	43974.5	2	UniProt (Q6P988) Pfam (PF03283)	HOMO SAPIENS (HUMAN)	NOTUM
2	C, E (A, B)	Myristoleic acid	non-polymer		226.4	2	Chemie (MYZ)
3	D (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
4	F, G (A, B)	water	water		18.0	45	Chemie (HOH)

Sequence modifications

A, B: 81 - 451 (UniProt: Q6P988)

PDB	External Database	Details
Glu 78	-	expression tag
Thr 79	-	expression tag
Gly 80	-	expression tag
Gly 452	-	expression tag
Thr 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag
Ala 232	Ser 232	engineered mutation
Ser 330	Cys 330	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87949.1
Non-Polymers*	Number of molecules	3
	Total formula weight	673.9
All*	Total formula weight	88623.0

*Water molecules are not included.